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The main symptoms associated with Erythema Nodosum is pain, swelling, joint pain, an overall sick feeling Leczenie Rumienia i Trądziku Różowatego , pain, pain, pain plus more pain. I have not had the opportunity to wear shoes for around a week and also have been sporting my lovely slippers everywhere I go. Sleeping isn't easy either. If the sheets touch the spots, it hurts like hell.