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Check out our new paper on the genetics of Ebola susceptibility in bats at eLife ( We show that NPC1 has indeed undergone accelerated evolution in bats, and present evidence that this is one outcome of an evolutionary arms race between filoviruses and bats. 
Kartik Chandran (

Problem with this idea: the NPC1 binding site in GP is only exposed in endosomes after proteolytic cleavage. A receptor decoy would be unable to access and block GP efficiently. Potential solution: target such a decoy to endosomes. We are working on this.
-Kartik Chandran (